Frontiers of Medicine
Pages 855-866
doi:10.1007/s11684-023-1026-6
Abstract:
separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STINGAt the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis.signaling, including cGAS condensates, STING condensates, and IRF3 condensates.These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide newHere, we summarize recent advances in the phase separation of cGAS-STING signaling and the development